CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION

Abstract

Relevance. Breast cancer remains one of the most common and socially significant malignancies among women. Given the high frequency of mastectomies, the risk of locoregional recurrences remains substantial, necessitating the development of effective diagnostic, surveillance, and therapeutic algorithms. Objective. To identify clinical, morphological, and molecular risk factors for breast cancer recurrence and to propose a stratification system and personalized approach to treatment and follow-up. Materials and methods of the study. The study included 206 patients with verified breast cancer who underwent mastectomy. Imaging, immunohistochemical (IHC) typing, and tumor marker monitoring were used. Molecular subtypes, Ki-67 index, and completeness of therapy were assessed. Statistical analysis was performed using the StatTech environment. Research results. A high recurrence risk was found in patients with HER2-positive and triple-negative tumors, stage IIB–IIIA, and high Ki-67 levels. Incomplete adjuvant therapy significantly increased recurrence probability. A follow-up algorithm and risk stratification system were developed. Conclusion. Locoregional breast cancer recurrences are associated with tumor biology and insufficient treatment. Therapy individualization based on IHC profiles improves survival and reduces oncological burden.