Vol. 5 No. 3 (2026): May-June
53-61
2026-06-29
Open Access

CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION

Gulnara N. Rakhimova
Nasiba U. Alimova
Kamola I. Khalmatova
https://doi.org/10.56121/MSU-2026-3-00019

Received: 2026-03-26

Published: 2026-06-29

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Abstract

Objective. To comparatively evaluate the diagnostic performance of different methods for estimating glomerular filtration rate (GFR) in children and adolescents with type 1 diabetes mellitus (T1DM), depending on the stage of chronic kidney disease (CKD).


Materials and Methods. This single-center cross-sectional study included 45 patients with T1DM (23 males and 22 females; median age, 15.5 years). Descriptive, correlation (Spearman), and regression analyses were performed.


Results. A marked discrepancy was found in CKD stage distribution depending on the method used to calculate GFR. Based on creatinine, 88.4% of patients were classified as stage C1, whereas according to the CKiD 2012 formula, only 29.5% were classified as C1, 65.9% as C2, and 4.5% as C3a. HbA1c (β=2.719; p=0.008) and TIR (β=0.222; p=0.015) were independent risk factors for GFR estimated by CKiD 2012 (R²=0.394).


Conclusion. The study results showed that the CKiD 2012 formula demonstrated the highest diagnostic performance for cystatin C-based estimation of GFR.

Keywords

List of references

  1. International Diabetes Federation. IDF Diabetes Atlas, 10th edition. Brussels: IDF; 2021. Available from: https://diabetesatlas.org

  2. Ogle GD, James S, Dabelea D, et al. Global estimates of incidence of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Atlas, 10th edition. Diabetes Res Clin Pract. 2022;183:109083. https://doi.org/10.1016/j.diabres.2021.109083

  3. Алимова Н.У., Рахимова Г.Н. Эпидемиология и лечение детей и подростков с сахарным диабетом 1 типа в Узбекистане в ходе проведения регистра. Монография.

  4. Alimova NU, Rakhimova GN. Epidemiological data of type 1 diabetes mellitus in children in Uzbekistan, 1998–2014. Pediatric Diabetes. 2018;19(S27):158-165.

  5. Рахимова Г.Н., Алимова Н.У., Халматова К.И. Эпидемиологические показатели СД 1 типа среди детей и подростков в Республике Узбекистан. ZDIT. 2025;4(35):50-51. https://doi.org/10.5281/zenodo. 17481319

  6. Rossing P, Groop PH, Singh R, et al. Prevalence of Chronic Kidney Disease in Type 1 Diabetes Among Adults in the U.S. Diabetes Care. 2024;47(8):1395-1399. https://doi.org/10.2337/dc24-0335

  7. Boettcher C, Utsch B, Galler A, et al. Estimated Glomerular Filtration Rates Calculated by New and Old Equations in Children and Adolescents With Type 1 Diabetes. Front Endocrinol (Lausanne). 2020;11:52. https://doi.org/10.3389/fendo.2020.00052

  8. Benoit SW, Ciccia EA, Devarajan P. Cystatin C as a biomarker of chronic kidney disease: Latest developments. Expert Rev Mol Diagn. 2020;20(10):1019-1026. https://doi.org/10.1080/14737159.2020.1796624

  9. Dahl H, Meyer K, Sandnes K, et al. Cystatin C proteoforms in chronic kidney disease. PLoS ONE. 2023;18(1):e0269436. https://doi.org/10.1371/journal.pone.0269436

  10. Battelino T, Alexander CM, Amiel SA, et al. Continuous glucose monitoring and metrics for clinical trials: an international consensus statement. Lancet Diabetes Endocrinol. 2023;11(1):42-57. https://doi.org/10.1 016/S2213-8587(22)00319-9

  11. Guo Q, Zang P, Xu S, et al. Time in Range Is Reversely Associated with Diabetic Cardiovascular Autonomic Neuropathy. J Diabetes Res. 2020;2020:5817074. https://doi.org/10.1155/2020/5817074

  12. Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol. 2009;4(11):1832-1843. https://doi.org/10.2215/CJN.01640309 [formula reference]

  13. Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol. 2003;18(10):981-985. https://doi.org/10.1007/s00467-003-1271-5 [formula reference]

  14. Schwartz GJ, Schneider MF, Maier PS, et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney Int. 2012;82(4):445-453. https://doi.org/10.1038/ki.2012.169 [CKiD 2012 formula]

  15. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.

  16. Kidney Int. 2024;105(4S):S117-S314. https://doi.org/10.1016/j.kint.2023.10.018

  17. He D, Gao B, Wang J, et al. Difference Between Cystatin C- and Creatinine-Based eGFR and Risk of Diabetic Microvascular Complications. Diabetes Care. 2024;47(5):873-880. https://doi.org/10.2337/dc23-1818

  18. Bjornstad P, Dart A, Donaghue KC, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes. Pediatr Diabetes. 2022;23(8):1432-1457. https://doi.org/10.1111/pedi.13444

  19. Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021;385(19):1737-1749. https://doi.org/10.1056/NEJMoa2102953

  20. KDIGO Diabetes Work Group. KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2022;102(5S):S1-S127. https://doi.org/10.1016/j.kint.2022.06.008

About the Authors

Gulnara N. Rakhimova
diabetgulnora@hotmail.com
Center for the Development of Professional Qualifications of Medical Workers
Nasiba U. Alimova
nasiba_ali@mail.ru
Republikcan Scientific and Practical Medical Center of Endocrinology Named After Academician Y.H. Turakulov
Kamola I. Khalmatova
kamairgasheva@gmail.com
Republikcan Scientific and Practical Medical Center of Endocrinology Named After Academician Y.H. Turakulov

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CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION. MSU [Internet]. 2026 Jun. 29 [cited 2026 Oct. 13];5(3):53-61. Available from: https://fdoctors.uz/index.php/journal/article/view/288
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