PATHOMORPHOLOGY OF CHANGES IN ALVEOLAR STRUCTURES OF THE LUNGS IN PNEUMOPATHIES AT DIFFERENT PERIODS OF GESTATION

Abstract

Pathomorphological changes in the alveolar structures of the lungs of fetuses and newborn infants who died from various forms of pneumopathy were noted at 22-28 weeks of gestation: total atelectasis, diapedetic hemorrhages, desquamation of the mucous epithelium of the bronchioles, at 29-31 and 32-36 weeks of gestation: small scattered primary atelectasis, hyaline membranes, edematous-hemorrhagic changes, at 38-40 weeks gestation and in newborns on days 1-7 edematous-hemorrhagic and atelectatic changes, and on days 8-28 of gestation edematous-hemorrhagic changes.  Relevance: Pneumopathy occupies a special place among respiratory diseases of newborns [1, 2, 6]. UNICEF studies have noted that pneumopathies cause stillbirths and death of newborns with disabilities in many countries of the world [3, 4, 5]. The aim and objectives of the study are to study the pathomorphological changes in various forms of pneumopathies in fetuses and newborns of different gestational ages. Materials and methods - The study studied the alveolar structures of the lungs of fetuses and newborns who died of pneumopathies in maternity hospitals of Andijan region in 2020-2024.  Research results: At 18-22 weeks, the formation of 3rd-order respiratory bronchioles, alveolar clefts, and sacs, the alveolar appearance of 3rd-order bronchioles, and the formation of fetal arteries were observed.