MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY
Abstract
Endothelial dysfunction plays a leading role in the progression of cardiovascular disease in children with obesity. The article discusses the prognostic values of early markers of endothelial dysfunction in children with obesity. The aim of the study: to study early markers of endothelial dysfunction in children and adolescents with abdominal obesity to predict the development of cardiovascular risk. Materials and methods: A total of 56 obese children aged 10-18 years were examined on an outpatient basis. Anthropometric, general clinical and biochemical studies of the lipid and carbohydrate spectrum were performed in all study groups. The levels of leptin, trimethylamine-N-oxide (TMAO) and von Willebrand factor (vWF) were determined in plasma by enzyme-linked immunosorbent assay (ELISA). Study results: A close relationship between severe obesity in children with hyperleptinemia and leptin resistance was revealed. The highest values of the von Willebrand factor content and TMAO level were found in children with abdominal obesity. In children with a uniform type of obesity, these indicators had moderate values. Conclusion: Leptin resistance, elevated levels of TMAO and von Willebrand factor lead to endothelial dysfunction and, accordingly, a high risk of developing cardiovascular pathology in children with abdominal obesity.
Keywords:
About the Authors
List of references
Лындина М. Л., Шишкин А. Н., Тесля О. В. Особенности ранней диагностики эндотелиальной дисфункции у больных с метаболическим синдромом // Вестн. СПбГУ. Сер.: 11. Медицина. – 2014. – № 3. – С. 56–64.
Brunt VE, Casso AG, Gioscia-Ryan RA, et al. Gut microbiome- derived metabolite trimethylamine N-oxide induces aortic stiffening and increases systolic blood pressure with aging in mice and humans. Hypertension. 2021;78(2):499-511.
Canyelles M, Borràs C, Rotllan N, Tondo M, Escolà-Gil JC, Blanco-Vaca F. Gut Microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease? Int J Mol Sci. 2023;24(3):1940.
Chen G, He L, Dou X, Liu T. Association of trimethylamine-N-oxide levels with risk of cardiovascular disease and mortality among elderly subjects: a systematic review and meta-analysis. CardioRenal Med. 2022;12(2):39-54.
Dehghan P, Farhangi MA, Nikniaz L, Nikniaz Z, Asghari-Jafarabadi M. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) potentially increases the risk of obesity in adults: an explora-tory systematic review and dose-response meta- analysis. Obes Rev. 2020;21(5):e12993.
Genovesi S., Giussani M., Orlando A., Lieti G., Viazzi F., Parati G. Relationship between endothelin and nitric oxide pathways in the onset and maintenance of hypertension in children and adolescents. Pediatr. Nephrol. 2022; 37(3): 537–45.
Hernández Morante J.J., Díaz Soler I., Muñoz J.S.G., Sánchez H.P., Barberá Ortega M.D.C., Martínez C.M., et al. Moderate weight loss modifies leptin and ghrelin synthesis rhythms but not the subjective sensations of appetite in obesity patients. Nutrients. 2020; 12(4): 916.
La Cava A. Leptin in inflammation and autoimmunity. Cytokine. 2017; 98: 51–8.
Lawler K., Huang-Doran I., Sonoyama T., Collet T.H., Keogh J.M., Henning E., et al. Leptin-mediated changes in the human metabo lome. J. Clin. Endocrinol. Metab. 2020; 105(8): 2541–52.
Li D, Lu Y, Yuan S, et al. Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an um-brella review and updated meta-analysis. Am J Clin Nutr. 2022;116(1):230-243.
Peng J., Yin L., Wang X. Central and peripheral leptin resistance in obesity and improvements of exercise. Horm. Behav. 2021; 133:105006.
Perdoncin M., Konrad A., Wyner J.R., Lohana S., Pillai S.S., Pereira D.G., et al. A review of miRNAs as biomarkers and effect of dietary modulation in obesity associated cognitive decline and neurodegenerative disorders. Front. Mol. Neurosci. 2021; 14: 756499.
Russo B., Menduni M., Borboni P., Picconi F., Frontoni S. Autonomic nervous system in obesity and insulin-resistance-the complex interplay between leptin and central nervous system. Int. J. Mol. Sci. 2021; 22(10): 5187.
Tang WHW, Wang Z, Levison BS, et al. Intestinal microbial metab-olism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575-1584.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.