No. 1 (2024): January-February
13-17
2024-02-14
Open Access

STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA

Usanov Sanjar Sadinovich
Abduraimov Zafarjon Abduraimovich
DOI: https://doi.org/10.56121/2181-3612-2024-1-13-17

Received: 2024-03-01 15:31:08

Published: 2024-02-14

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Abstract

Objective: To study morphometric changes in the structure of the liver of white rats with polypharmacy with anti-inflammatory drugs.


Methods: The study was carried out on 50 male white rats, weighing from 210 to 320 g, kept in a vivarium with a standard diet, free access to water, and a normal lighting regime. The animals were divided into 3 groups.


Results: When comparing the morphometric parameters of the rats of the 3rd group with those of the 2nd group, a significant decrease was found. The area of the hepatic cell decreased 5.14%, 5.05%, 3.19% and 3.02%, the outer diameter of the central vena decreased 8.13%, 6.11%, 4.08% and 3.42%, the diameter of the biliary duct decreased by 6.33%, 5.09%, 3.12% and 3.08%, the outer diameter of the arterial decreased by 7.12%, 5.07%, 5.03% and 4.48%, the diameter of the hepatic biliary duct decreased by 4.47%, 4.04%, 3.07% and 2.31%.


Conclusions. The presence of the effect of polypharmacy by anti-inflammatory drugs on the liver indicates that polypharmacy has a detrimental effect on urinary excretion, reduces biliary excretion and has a sufficient level of risk for the body.

Keywords

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About the Authors

Usanov Sanjar Sadinovich
usanovsanjar@gmail.com
Samarkand State Medical University
Abduraimov Zafarjon Abduraimovich
abduraimov.zafarjon90@gmail.com
Samarkand State Medical University
https://orcid.org/0000-0002-2927-0712 (unauthenticated)

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How to Cite

1.
STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA. MSU [Internet]. 2024 Feb. 14 [cited 2026 Mar. 2];(1):13-7. Available from: https://fdoctors.uz/index.php/journal/article/view/64
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