TIC EPILEPSY IN THE UZBEK POPULATION: CLINICAL AND ENCEPHALOGRAPHIC ASPECTS (PILOT STUDY)

Abstract

Relevance. Tic disorders in children are one of the most common forms of hyperkinesis in pediatric neurological practice, demonstrating a high incidence of comorbidity with various neuropsychiatric and neurological disorders. One of these conditions, which has a significant impact on the course and prognosis of the disease, is epilepsy. The aim of the study was to carry out a clinical and physiological study to analyze the pathogenesis and clinical characteristics of epilepsy in children with tic hyperkinesis. Materials and methods of research. The present study analyzes the pathophysiological and clinical features of 189 children with tic hyperkinesis, 19 of them with concomitant epilepsy. The results of the study. Analysis of the data obtained suggests that there is a common pathogenetic basis between tic disorders and epilepsy. It is assumed that both conditions may be caused by dysfunction of the corticostriato-thalamo-cortical ring, which plays a key role in regulating motor activity, filtering sensory information, and implementing cognitive-behavioral programs. Conclusion. Epilepsy is one of the comorbid pathologies associated with tic hyperkinesis in children, and early electroencephalographic examination in children with tics will allow verification of epileptic activity for further rational patient management. Keywords: tic disorders, hyperkinesis, epilepsy, children, comorbidity, YGTSS, cortico-striato-thalamo-cortical system, neurophysiology.