PLATELET-RICH PLASMA (PRP): USE IN WOMEN WITH IMPAIRED REPRODUCTIVE FUNCTION, AFTER MISSED MISSCARIAGE

FULL TEXT:

Abstract

In this study, we used a new method of endometrial restoration with platelet-rich plasma and the effect of plasma on the endometrium was proven. The purpose of the study is to evaluate the efficacy of platelet-rich plasma (PRP) on the endometrium. The research methods included clinical-anamnestic, clinical-laboratory, ultrasound with the use of Doppler, enzyme-linked immunosorbent assay and statistical. Results of the study: A total of 80 women with a history of NB were examined and studied prospectively, divided into two subgroups: IA – 40 patients who received complex treatment with plasma therapy as part of preconception preparation, in this group, 33 patients with pregnancy underwent clinical observation up to 22 weeks; Ib – 40 patients who received standard therapy. The control group consisted of 50 healthy pregnant women up to 22 weeks without a burdened obstetric history - no history of miscarriage. Conclusion: Thus, after complex treatment, including sweat therapy, there was a restoration of hemodynamics at all levels of the vascular tree of the uterus. The main advantage was proven by the onset and favorable course of pregnancy in 82.5% of cases.

About the Authors

List of references

Julkunen M, Wahlstrom T, Seppälä M. Human fallopian tube contains placental protein 14. American Journal of Obstetrics and Gynecology. 1986;154(5):1076-1079;

Du J. et al. Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: a protocol for systematic review and meta-analysis //Medicine. – 2020. – Т. 99. – №. 3

Сулаева О.И. Получение богатой тромбоцитами плазмы:мифы и реальность// ISSN 2079-8334. Світ медицини та біології. 2017. № 3(61), стр.150-153. DOI 10.26724 / 2079-8334-2017-3-61-150-153

. Пальцев М.А., Кветной И.М. Руководство по нейроиммуноэндокринологии. — 2 е изд. — М.: Медицина, 2008. — 512 с

Achache H., Revel A. Endometrial receptivity markers, the journey to successful embryo implantation // Hum. Reprod. Update. — 2006. — Vol. 12, N 6. — P. 731–746;

Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis / Garcia-Velasco J.A. // J. Fertil. Steril. — 2002. — Vol. 78. — P. 855–859.

Добродицкая А. Д. и др. КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ВЫЯВЛЕНИЯ ТРОМБОФИЛИИ У БЕРЕМЕННЫХ С ОТЯГОЩЕННЫМ АКУШЕРСКИМ АНАМНЕЗОМ С ЦЕЛЬЮ ПРОФИЛАКТИКИ АНТЕНАТАЛЬНОЙ ГИБЕЛИ ПЛОДА //Клинические и медико-организационные решения по сохранению репродуктивного здоровья семьи. – 2017. – С. 77-80;

Maleki-Hajiagha A. et al. Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis //Journal of reproductive immunology. – 2020. – Т. 137. – С. 103078.

. Sharara F. I. et al. A narrative review of platelet-rich plasma (PRP) in reproductive medicine //Journal of Assisted Reproduction and Genetics. – 2021. – Т. 38. – С. 1003-1012;

Aghajanova L., Cedars M. I., Huddleston H. G. Platelet-rich plasma in the management of Asherman syndrome: case report //Journal of assisted reproduction and genetics. – 2018. – Т. 35. – С. 771-775

Du J. et al. Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: a protocol for systematic review and meta-analysis //Medicine. – 2020. – Т. 99. – №. 3

Mouanness M. et al. Use of intra-uterine injection of platelet-rich plasma (PRP) for endometrial receptivity and thickness: a literature review of the mechanisms of action //Reproductive Sciences. – 2021. – Т. 28. – С. 1659-1670.

Tang R. et al. Clinical evaluation of autologous platelet-rich plasma therapy for intrauterine adhesions: a systematic review and meta-analysis //Frontiers in Endocrinology. – 2023. – Т. 14

Soliman A. et al. How autologous platelet-rich plasma affects pregnancy and birth outcomes in women with repeated embryo implantation failure: A prisma-compliant meta-analysis //Turkish Journal of Obstetrics and Gynecology. – 2023. – Т. 20. – №. 2. – С. 154

Liu K. et al. Autologous platelet‐rich plasma intrauterine perfusion to improve pregnancy outcomes after implantation failure: A systematic review and meta‐analysis //Journal of Obstetrics and Gynaecology Research. – 2022. – Т. 48. – №. 12. – С. 3137-3151;

Maged A. M. et al. The value of platelet-rich plasma in women with previous implantation failure: A systematic review and meta-analysis //Journal of Assisted Reproduction and Genetics. – 2023. – Т. 40. – №. 5. – С. 969-983;

Jin X. H., Li Y., Li D. Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis //Frontiers in Endocrinology. – 2022. – Т. 13. – С. 959121

Носкова И. Н., Артымук Н. В. Эффективность преконцепционной интравагинальной пелоидотерапии у женщин с потерей беременности в ранние сроки // Мать и дитя в Кузбассе. 2012. № Спецвыпуск 1. С. 113-118. URL: https://cyberleninka.ru/article/n/effektivnost-prekontseptsionnoy-intravaginalnoy-peloidoterapii-u-zhenschin-s-poterey-beremennosti-v-rannie-sroki

Нигаметзянова Г. Р. Неразвивающаяся беременность // Лечение и профилактика. 2017. № 2. С. 47-55. URL: https://readera.org/nerazvivajushhajasja-beremennost-143162918;

Views: 46