SUT BEZI SARATONIDAN SO‘NG RADIKAL MASTEKTOMIYADAN KEYINGI LOKAL-REGIONAL QAYTALANISH: XAVF OMILLARI, DIAGNOSTIKA VA HUDUDIY BOSHQARUV STRATEGIYALARI
Abstrakt
Mavzuning dolzarbligi. Sut bezi saratoni (SBS) bo‘yicha radikal mastektomiyadan keyingi lokal-regional qaytalanish (LRQ) og‘ir klinik muammo hisoblanadi va tiriklik darajasining pasayishi bilan bog‘liq. Maqsad. LRQ uchun xavf omillarini baholash hamda samarali kuzatuv va davolash strategiyalariga oid hududiy tavsiyalarni ishlab chiqish. Tadqiqot materiallari va usullari. 2017–2024 yillar davomida Samarqand viloyatida davolangan 206 nafar SBS bilan kasallangan bemorlarning retrospektiv-prospektiv tahlili o‘tkazildi. Tadqiqotda o‘simta xususiyatlari, molekulyar profili, davolash usullari, qaytalanish joylashuvi va omon qolish natijalari tahlil qilindi. Natijalar. LRQ darajasi 5,4%ni tashkil etdi. Qaytalanish holatlari asosan 31–50 yoshdagi ayollarda va IIB–IIIA bosqichdagi o‘simtalar fonida kuzatildi. Gormon retseptorlari holati, HER2 ekspressiyasi, Ki-67 indeksi hamda adjuvant terapiyaning to‘liqligi asosiy prognoz ko‘rsatkichlari bo‘ldi. Molekulyar stratifikatsiya va hududiy resurslarga asoslangan taklif etilgan boshqaruv algoritmi uzoq muddatli natijalarni yaxshilash imkoniyatini namoyish etdi. Xulosa. O‘simta biologiyasini va hududiy ko‘rsatkichlarni inobatga olgan holda, individual kuzatuv va davolash rejalari LRQ darajasini kamaytirish va bemorlarning yashash ko‘rsatkichlarini yaxshilash uchun muhim ahamiyatga ega.
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Djurayev MD, Uzokov SM, Kutlumuratov AB, Esankulova BS. To the question of the risk of poctmastectomic lymphedema in patients with breast cancer and its connection with concomitant vascular pathology. Science and Innovation. 2023 Oct 31;2(10). doi:10.5281/zenodo.10057478.
Djurayev MD, Uzokov SM, Kutlumuratov AB, Esankulova BS. Whether exist links between toxic injury and risk of poctmastectomic lymphedema in breast cancer patients? Science and Innovation. 2023 Oct;2(10). UIF-2022: 8.2. Available from: https://scientists.uz
Eiermann W, Peapke D, Appfelstaedt J, et al. Preoperative treatment of postmenopausal breast cancer patients with letrozole: a randomized double-blind multicenter trial. Ann Oncol. 2001;12:1527–1532.
Elkhuizen PH, van Slooten HJ, Clahsen PC, et al. High local recurrence risk after breast-conserving therapy in node-negative premenopausal breast cancer patients is greatly reduced by one course of perioperative chemotherapy: a European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study. J Clin Oncol. 2000;18:1075–1083.
National Center for Biotechnology Information (NCBI). Entrez Gene: ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2. Available from: https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2064
Ferguson CM, Swaroop MN, Horick N, et al. Impact of ipsilateral blood draws, injections, blood pressure measurements, and air travel on the risk of lymphedema for patients treated for breast cancer. J Clin Oncol. 2016;34:691–698.
Улмасов ФГ, Джураев МД, Эсанкулова БС, Ортикова ХУ. Значение комбинированных и мультивисцеральных резекций при лечении злокачественных опухолей в забрюшинном пространстве. Eurasian Journal of Oncology. 2024;12(2):214–220. doi:10.34883/PI.2024.12.2.026.
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