LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES

Abstract

Relevance. Locoregional recurrence (LRR) of breast cancer (BC) following radical mastectomy presents a significant clinical challenge and is associated with reduced survival. Objective. To assess the risk factors for LRR and develop regional recommendations for effective surveillance and treatment strategies. Materials and methods of the study. A retrospective-prospective analysis of 206 breast cancer patients treated between 2017 and 2024 in the Samarkand region was conducted. The study focused on tumor characteristics, molecular profiles, treatment modalities, recurrence localization, and survival outcomes. Research results. The LRR rate was 5.4%. Most recurrences occurred in women aged 31–50 and in patients with stage IIB–IIIA tumors. Hormone receptor status, HER2 expression, Ki-67 index, and completeness of adjuvant therapy were significant predictors of recurrence. The proposed management algorithm, based on molecular stratification and regional resources, demonstrated potential for improving long-term outcomes. Conclusion. Personalized follow-up and therapy plans based on tumor biology and regional guidelines are essential for reducing recurrence and improving survival in postmastectomy breast cancer patients.