YUVENIL IDIOPАTIK АRTRIT BILAN KASALLANGAN NEFROPATIYASI BOR BEMORLARDA SITOKINLАR

Karimjanov Ilkhom Asomovich
Madaminova Malika Shavkatovna
Umarov Doniyor Azadbekovich
Turakhulova Qurbanoy Xasan qizi
Nashr sanasi https://doi.org/10.56121/2181-3612-2025-2-35-39
TO'LIQ MATN:

Abstrakt

Tadqiqot maqsadi: Yuvenil idiopatik artrit va buyrak shikastlanishining erta tashxisida proyallig`lanish sitokinlarning rolini aniqlash. Materiallar va metodlar: Tadqiqotga 2021-2023 yillarda TTА koʼp tarmoqli tibbiyot markazining kardio-revmatologiya boʼlimida davolangan bemorlar haqidagi maʼlumotlar kiritilgan. Ularning orasidan: 105 ta yuvenil idiopatik artrit bilan kasallangan bemorlar, ular asosiy guruhni tashkil etadi. Nazorat guruhi esa Chilonzor tumani №35 Oilaviy poliklinikasida dispanser kuzatuvi otayotgan 30 ta amaliy sogʼlom bolalardan tashkil topdi. Har bir tadqiqot qilinayotgan bemorga chuqur klinik-immunologik va laborator-instrumental tekshiruvlar oʼtkazilgan. Natijalar: Tadqiqotdan kelib chiqib, bizning o`rganishda yuvenil idiopatik artritning davom etishi 3 oydan 8 yilgacha va koʼproq katta va oʼrta bo'g'imlar zararlanishi (tizza, boldir-tovon, tirsak) ko`rsatdi. Kasallikning persistlovchi kechuvi 28,9% bemorlarda va progressiv kechuvi 71% kuzatildi. Dalillarga koʼra, bolalarda bo`gim zararlanishi jinsga koʼra, oʼgʼil bolalarda ekssudativ komponentning kamroq ekanligi (39%), pastki bo`gimlarda produktiv-distrofik oʼzgarishlarning koʼproq (61%) namoyishi boʼlgan. Qizlarda esa yuqori bo`gimlarda ekssudatsiya 85% boʼlgan. Bemorlarning oʼrtacha yoshi 7 yoshni tashkil qildi. Rentgenologik tekshiruv natijalari asosan Shteynbrokker boʼyicha II darajani koʼrsatgan. Yuvenil idiopatik artrit bilan kasallangan bemorlarda, proyallig'lanish sitokinlar darajasi 5-10 baravar, kasallikning variantlariga qarab ko'payadi. Xulosa: Yuvenil idiopatik artrit kasallikning zamonaviy davrda rivojlanishi, shuningdek ichki organlarning shikastlanishini aks ettiruvchi kasallikning tajovuzkorligi va progressiv tusidir. Ayniqsa, buyraklar zararlanishining va kasallikning o`gir kechishini oldini olishning samarali usullarini izlash zarurligini  ta'kidlaydi. Ya'ni proyallig'lanish sitokinlar (TNF-α), qon zardobida 2 martadan ko'proq YUAning dastlabki tashxisini qo'yish uchun ishlatilishi mumkin.

Nashr sanasi

Mualliflar haqida

Karimjanov Ilkhom Asomovich
Toshkent tibbiyot akademiyasi
Madaminova Malika Shavkatovna
Toshkent tibbiyot akademiyasi
Umarov Doniyor Azadbekovich
EMU Universiteti
Turakhulova Qurbanoy Xasan qizi
Toshkent tibbiyot akademiyasi

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How to Cite

1.
Karimjanov I, Madaminova M, Umarov D, Turakhulova Q. YUVENIL IDIOPАTIK АRTRIT BILAN KASALLANGAN NEFROPATIYASI BOR BEMORLARDA SITOKINLАR. MSU [Internet]. 2025 Apr. 16 [cited 2025 Apr. 20];(2):35-9. Available from: https://fdoctors.uz/index.php/journal/article/view/113
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