RISK FACTOR FOR RENAL AMYLOIDOSIS IN ARTICULAR-VISCERAL FORM OF JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN

Abstract

Currently, juvenile idiopathic arthritis (JIA) has become a medical and social problem. This is fundamentally associated with a significant increase in the number of diseases among children, often with severe, progressive courses and early development of disability. The purpose of the study is to determine the risk factor for the development of renal amyloidosis in the articular-visceral form of JIA in children. Material and methods. We examined 30 children from 3 to 14 years old with the articular-visceral form of JIA against the background of immunodiathesis (autoimmune + lymphatic) (ID). The control group consisted of 25 practically healthy children of the same age. The clinical diagnosis was established on the basis of anamnesis, results of clinical laboratory, immunological, functional examination and diagnostic criteria for JIA. Results. In patients with the articular-visceral form of JIA against the background of ID, symptoms of kidney damage were periodically observed: decrease in daily diuresis, relative density of urine, decrease in glomerular filtration; an increase in selective proteinuria, erythrocyturia, leukocyturia, an increase in creatinine in the urine. Immunological changes were manifested in a decrease in CD3, CD8, CD, PhAN and an increase in CD19, IgA, IgM, IgG, IgE, CIC in the blood serum. Conclusions. 1. In children with juvenile idiopathic arthritis, immunodiathesis (autoimmune + lymphatic) is a risk factor for renal amyloidosis, which is based on interrelated and interdependent immunopathological processes that are characteristic of autoallergic pathologies, manifested by secondary immunological deficiency. 2. The process of development of renal amyloidosis in the articular-visceral form of JIA in children with immunodiathesis (autoimmune + lymphatic) is latent and progressive.