THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE

Abstract

Relevance. Parkinson's disease is a neurodegenerative disease of the nervous system and one of the most topical problems in neurology. Motor fluctuations are a common complication of long-term levodopa treatment in patients with Parkinson's disease. Рurpose of the study. To study the effect of motor fluctuations on the psychoemotional state and quality of life of patients with Parkinson's disease. Materials and methods of the study. The study included 120 patients with various clinical forms of Parkinson's disease. To compare the parameters during the study, the patients were divided into 2 groups: patients with motor fluctuations (55 people) and patients without motor fluctuations (65 people). All patients underwent clinical neurological and neuropsychological examinations. Research results. In the group with motor fluctuations, the comorbid form of affective disorders, that is, depression + anxiety, was significantly higher: in the group with fluctuations - 54.5% (30/55 patients), in the group without fluctuations - 24.6% (16/65 patients). When assessing the significance of this difference using the χ² test, the obtained value was p<0.01. Thus, it can be noted that motor fluctuations are strongly associated with more severe and comorbid forms of mental disorders (depression and anxiety). The results obtained based on the PDQ-39 scale domains show that psychoemotional disorders have varying degrees of negative impact on virtually all areas of life. Conclusion. When assessing quality of life using the PDQ-39 questionnaire, patients with anxiety and depression showed a significant decrease in indicators such as mobility, daily activities, emotional state, cognitive function, and social support. The greatest negative impact was observed in the group with comorbid depression and anxiety.