Jild 5 № 3 (2026): May-Iyun
53-61
2026-06-29
Ochiq kirish

O‘ZBEK POPULYATSIYASIDA 1-TUR QANDLI DIABETI BO‘LGAN BOLALAR VA O‘SMIRLARDA SISTATIN C BO‘YICHA HISOBLANGAN GLOMERULYAR FILTRATSIYA TEZLIGINI ANIQLASHNING KLINIK-DIAGNOSTIK AHAMIYATI

Gulnara N. Raximova
Nasiba U. Alimova
Kamola I. Xalmatova
https://doi.org/10.56121/MSU-2026-3-00019

Qabul qilingan: 2026-03-26

Nashr etilgan: 2026-06-29

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Annotatsiya

Maqsad. Tadqiqotning maqsadi — 1-tur qandli diabet (QD1) bilan og‘rigan bolalar va o‘smirlarda surunkali buyrak kasalligi (SBK) bosqichiga qarab glomerulyar filtratsiya tezligini (GFT) turli usullar yordamida aniqlashning diagnostik samaradorligini qiyosiy baholash.


Materiallar va usullar. Bir markazli ko‘ndalang kesimli tadqiqotga QD1 bilan og‘rigan 45 nafar bemor (23 nafar erkak, 22 nafar ayol; yosh medianasi 15,5 yil) kiritildi. Tavsifiy, korrelyatsion (Spearman) va regressiya tahlillari o‘tkazildi.


Natijalar. GFTni hisoblash usuliga qarab SBK bosqichlarining taqsimlanishida sezilarli tafovut aniqlandi: kreatinin bo‘yicha bemorlarning 88,4% C1 bosqichiga kiritilgan bo‘lsa, CKiD 2012 formulasi bo‘yicha atigi 29,5% C1 bosqichiga, 65,9% C2 bosqichiga va 4,5% C3a bosqichiga tasniflandi. HbA1c (β=2,719; p=0,008) va TIR (β=0,222; p=0,015) CKiD 2012 bo‘yicha GFT uchun mustaqil xavf omillari bo‘ldi (R²=0,394).


Xulosa. Tadqiqot natijalari sistatin C asosida GFTni aniqlashda CKiD 2012 formulasi eng yuqori diagnostik samaradorlikka ega ekanini ko‘rsatdi.

Kalit so‘zlar

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Mualliflar haqida

Gulnara N. Raximova
diabetgulnora@hotmail.com
Tibbiyot xodimlarining kasbiy malakasini rivojlantirish markazi
Nasiba U. Alimova
nasiba_ali@mail.ru
Republikcan Scientific and Practical Medical Center of Endocrinology Named After Academician Y.H. Turakulov
Kamola I. Xalmatova
kamairgasheva@gmail.com
Republikcan Scientific and Practical Medical Center of Endocrinology Named After Academician Y.H. Turakulov

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O‘ZBEK POPULYATSIYASIDA 1-TUR QANDLI DIABETI BO‘LGAN BOLALAR VA O‘SMIRLARDA SISTATIN C BO‘YICHA HISOBLANGAN GLOMERULYAR FILTRATSIYA TEZLIGINI ANIQLASHNING KLINIK-DIAGNOSTIK AHAMIYATI. MSU [Internet]. 2026 Jun. 29 [cited 2026 Oct. 13];5(3):53-61. Available from: https://fdoctors.uz/index.php/journal/article/view/288
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