BOLALARDA SEMIZLIKDA JIGAR QATTIQLIGI KO‘RSATKICHLARI, SILJISH TO‘LQINI ELASTOGRAFIYASI YORDAMIDA
Abstrakt
Resume: аsl maqolada semiz va normal tana vazniga ega bolalarda elastografiya usuli yordamida jigar parenximasining qattiqligi o‘rganilgan. Olingan natijalar pediatrlar va bolalar gastroenterologlarining amaliy faoliyatida qo‘llanilishi mumkin. Ishning maqsadi: Semizlik va alkogolsiz yog‘li jigar kasalligiga (AYJK) chalingan bemorlarda jigar ultratovush elastografiyasining diagnostik samaradorligini baholash. Materiallar va usullar: 68 nafar semizlik va alkogolsiz yog‘li jigar kasalligiga chalingan bola tekshirildi. Barcha bolalarda “Fibroskan” apparati yordamida jigar parenximasining qattiqligi aniqlandi. Tadqiqot natijalari: Olingan ma’lumotlar muhim prognostik ahamiyatga ega bo‘lib, AYJKning bolalarda uglevod va lipid almashinuvi buzilishi fonida visseral turdagi semizlikda jigar to‘qimalarida fibroz o‘zgarishlar shakllanishidagi patogenetik rolini tasdiqlaydi. ALT faolligining oshishi jigar metabolizmining buzilganini aks ettiradi va giparleptinemiya hamda leptinrezistentlik bilan bog‘liq yallig‘lanish jarayonining rivojlanishiga hamroh bo‘ladi. Xulosa: Visseral semizlikka ega bolalarda yallig‘lanish fonida metabolik jarayonlarning buzilishi jigar steatozining kuchayishiga va fibrozning shakllanishiga olib keladi, bu esa keyinchalik steatogepatit rivojlanishiga zamin yaratadi.
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Adabiyotlar ro'yxati
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