SEMIZ BOLALARDA PRO12ALA PPARG-2 (RS1801282) GENI POLIMORFIZMI
Abstrakt
Ishning maqsadi: turli turdagi semizlik bilan og'rigan bolalarda PPARG 2 genining Pro12Ala polimorfizmi chastotasini o'rganish. Materiallar va usullar: Semizligi bo’lgan 211 nafar va normal vaznga ega bo’lgan 104 nafar bolada Pro 12 Ala gen PPARG-2 polimorfizmini tashish tezligi o’rganildi. Molekulyar genetik tekshirish usuli qo'llanildi. Natijalar: Polimorfizmning Pro 12 Pro genotipi Pro 12 Ala geni izoformi PPARG-2 peroksis aktivatori geni bolalar va o’smirlarda semirishni, ya’ni abdominal semizlikni shakllantirish bilan bevosita bog’liqligi aniqlandi. AS bo’lgan bolalarda Pr12 Pro prekursor genotipi bo’lgan bo’lsa, metabolik buzilishlarsiz abdominal semizlik turi bo’lgan bolalarda esa 12Ala kichik allelining chastotasi MS ko’rinishidagi bolalarga nisbatan statistik jihatdan yuqori bo’lgan, bu esa ushbu allelni metabolik buzilishlarning rivojlanishi bo’yicha protektiv deb tasniflash imkonini beradi.
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