SEMIZLIGI BO‘LGAN BOLALARDA ENDOTELIAL DISFUNKSIYANING MARKERLARI
Abstrakt
Semizligi bor bo‘lgan bolalarda endotelial disfunktsiya yurak-qon tomir kasalliklarining rivojlanishida etakchi rol o'ynaydi. Maqolada semizligi bor bo‘lgan bolalarda endotelial disfunktsiyaning dastlabki belgilarining prognostik ahamiyati ko'rib chiqilgan. Tadqiqot maqsadi: kardiovaskulyar xavfining shaqillanishini prognostik qilish uchun abdominal semizlik bo‘lgan bolalar endotelial disfunktsiyaning dastlabki markerlarini o'rganish. Materiallar va usullar: 10-18 yoshdagi 56 semizligi bor bo‘lgan bolalar ambulator sharoitda tekshirildi. Barcha tadqiqot guruhlarida antropometrik, umumiy klinik va lipid va uglevod spektrining biokimyoviy tadqiqotlari o'tkazildi. Plazmadagi leptin, trimetilamin-N-oksid (TMAO) va Villebrand omili (vWF) darajalari immunoferment usuli bilan aniqlandi. Tadqiqot natijalari: Giperleptinemiya va leptinga rezistentligini semirish darajasi bilan o'rtasida bog'liqlik aniqlandi. Villebrand omili va TMAO darajasining eng yuqori ko'rsatkichlari abdominal semizlik bo‘lgan bolalarda bor edi. Birtekisda semizligi bor bo‘lgan bolalarda bu ko'rsatkichlar mu’tadil qiymatlarga ega edi. Xulosa: Leptinrezistentligi, TMAO va Villebrand omilining yuqori darajalari endotelial disfunktsiyaga olib keladi va shunga mos ravishda abdominal semizlik bo‘lgan bolalarda yurak-qon tomir patologiyasini rivojlanish xavfi yuqori bo’ladi.
Nashr sanasi
Mualliflar haqida
Adabiyotlar ro'yxati
Лындина М. Л., Шишкин А. Н., Тесля О. В. Особенности ранней диагностики эндотелиальной дисфункции у больных с метаболическим синдромом // Вестн. СПбГУ. Сер.: 11. Медицина. – 2014. – № 3. – С. 56–64.
Brunt VE, Casso AG, Gioscia-Ryan RA, et al. Gut microbiome- derived metabolite trimethylamine N-oxide induces aortic stiffening and increases systolic blood pressure with aging in mice and humans. Hypertension. 2021;78(2):499-511.
Canyelles M, Borràs C, Rotllan N, Tondo M, Escolà-Gil JC, Blanco-Vaca F. Gut Microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease? Int J Mol Sci. 2023;24(3):1940.
Chen G, He L, Dou X, Liu T. Association of trimethylamine-N-oxide levels with risk of cardiovascular disease and mortality among elderly subjects: a systematic review and meta-analysis. CardioRenal Med. 2022;12(2):39-54.
Dehghan P, Farhangi MA, Nikniaz L, Nikniaz Z, Asghari-Jafarabadi M. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) potentially increases the risk of obesity in adults: an explora-tory systematic review and dose-response meta- analysis. Obes Rev. 2020;21(5):e12993.
Genovesi S., Giussani M., Orlando A., Lieti G., Viazzi F., Parati G. Relationship between endothelin and nitric oxide pathways in the onset and maintenance of hypertension in children and adolescents. Pediatr. Nephrol. 2022; 37(3): 537–45.
Hernández Morante J.J., Díaz Soler I., Muñoz J.S.G., Sánchez H.P., Barberá Ortega M.D.C., Martínez C.M., et al. Moderate weight loss modifies leptin and ghrelin synthesis rhythms but not the subjective sensations of appetite in obesity patients. Nutrients. 2020; 12(4): 916.
La Cava A. Leptin in inflammation and autoimmunity. Cytokine. 2017; 98: 51–8.
Lawler K., Huang-Doran I., Sonoyama T., Collet T.H., Keogh J.M., Henning E., et al. Leptin-mediated changes in the human metabo lome. J. Clin. Endocrinol. Metab. 2020; 105(8): 2541–52.
Li D, Lu Y, Yuan S, et al. Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an um-brella review and updated meta-analysis. Am J Clin Nutr. 2022;116(1):230-243.
Peng J., Yin L., Wang X. Central and peripheral leptin resistance in obesity and improvements of exercise. Horm. Behav. 2021; 133:105006.
Perdoncin M., Konrad A., Wyner J.R., Lohana S., Pillai S.S., Pereira D.G., et al. A review of miRNAs as biomarkers and effect of dietary modulation in obesity associated cognitive decline and neurodegenerative disorders. Front. Mol. Neurosci. 2021; 14: 756499.
Russo B., Menduni M., Borboni P., Picconi F., Frontoni S. Autonomic nervous system in obesity and insulin-resistance-the complex interplay between leptin and central nervous system. Int. J. Mol. Sci. 2021; 22(10): 5187.
Tang WHW, Wang Z, Levison BS, et al. Intestinal microbial metab-olism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575-1584.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.