BRONXIAL ASTMA VA SURUNKALI OBSTRUKTIV O'PKA KASALLIGINING KOMBINATSIYALANGAN PATOLOGIYASI BO'LGAN BEMORLARDA ENDOTELIAL DISFUNKTSIYANING XUSUSIYATLARI
Abstrakt
Kirish. Jahon sog'liqni saqlash tashkilotima'lumotlariga ko'ra, nafas olish yo'llari infektsiyasidan (ori) o'lim darajasi har doim yuqori bo'lgan, dunyo aholisining o'limining 10 ta asosiy sabablari ro'yxatiga kiritilgan. [1,9,10] Bronxial astma (BA) va surunkali obstruktiv o'pka kasalligi (O’SOK) – surunkali bronxial obstruktsiya bilan tavsiflangan nafas yo'llarining patologiyalari. Ikkala kasallik ham atrof-muhit omillari va inson tanasining o'zaro ta'siri natijasida yuzaga keladi, bu esa turli xil klinik ko'rinishlarga olib keladi. Tadqiqot maqsadi: bronxial astma, surunkali obstruktiv o'pka kasalligi va ikkalasining kombinatsiyasi bo'lgan bemorlarda endotelial disfunktsiyani shakllantirishda azot oksidi metabolitlarining rolini baholash. Tadqiqot materiallari va usullari: Samarqand shahar tibbiyot birlashmasining pulmonologiya va allergologiya bo'limida 115 nafar bemor, shuningdek, 20 nafar sog'lom insonlar tekshirildi. Natijalar va xulosalar: Endotelial disfunktsiyani aniqlash uchun biz NCHK tarkibida ham, qonda ham NO2 va NO3 ko'rsatkichlarining nisbatlarini o'rganib chiqdik. Natijalar shuni ko'rsatdiki, O’SOK +BA bilan og'rigan bemorlarda kasallikning izolyatsiya qilingan turi (P<0,05; p<0,001) bilan solishtirganda NO2 va NO3 kontsentratsiyasi kuchaygan, bu kasallikning kombinatsiyalangan bosqichida endotelial tizim disfunktsiyasining yuqori darajasini tasdiqlaydi.
Mualliflar haqida
Adabiyotlar ro'yxati
Who. The Top 10 Causes Of Death. Accessed October 24, 2023. Https://Www.Who.Int/News-Room/Fact-Sheets/Detail/The-Top-10-Causes-Ofdeath.
Trushina E.Yu., Kostina E.M., Tipikin V.A., Orlova E.A. Modern Concepts of the Combination of Bronchial Asthma and Chronic Obstructive Pulmonary Disease 2023.
Ritesh Agarwal, Et Al. European Respiratory Journal 2021; Doi: 10.1183/13993003.01787-2021.
Nasirova A. A. Characteristics of the quality of life of patients with bronchial asthma, chronic obstructive pulmonary disease and their combination // Journal of Cardiorespiratory Studies. - 2022. - Vol. 3. - No. 3.
Shodikulova G. Z., Ellamonov S. N., Nasirova A. A. Frequency of occurrence of dilated cardiomyopathy in the Uzbek population // Bulletin of Science and Education. - 2020. - No. 13-2 (91). - P. 44-48.
Nasirova A. A., Sadikova Sh. N., Kurbanova Z. P. Modern concepts of the role of the surface phenotype of lymphocytes in chronic obstructive pulmonary disease and bronchial asthma and their treatment // Bulletin of Science and Education. – 2020. – No. 13-2 (91). – P. 49-53.
Babamuradova Z., Nasirova A., Iskandarov F. Endothelial dysfunction in chronic heart failure combined with diabetes mellitus // Journal of Cardiorespiratory Research. – 2021. – Vol. 2. – No. 3. – P. 49-52.
Akparova A.Yu., Abishev M.T., Elubaeva L.B., Bersimbay R.I., “Asthma-chronic obstructive pulmonary disease overlap syndrome: development mechanisms, diagnostic problems and prospects for targeted therapy”, Bulletin of the Kazakh National Medical University 2018, 122-127pp.
Belevsky A.S. "Asthma-chronic obstructive pulmonary disease overlap syndrome" 2016;
Luss L.V., Belousov Yu.B., Sidorovich O.I., Glushkova E.F. New possibilities in the treatment of bronchial asthma. Effective pharmacotherapy. Pulmonology and otolaryngology. 2017; 3(1): 10–16
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