POST-COVID DAVRIDA BRONXIAL ASTMALI BOLALARDA KLINIK-LABORATOR KO‘RSATKICHLAR O‘ZGARISHLARI VA ULARNING O‘ZARO BOG‘LIQLIGI
Abstrakt
Аnnotatsiya. COVID-19 pandemiyasi ko’plab surunkali kasalliklarning klinik kechishini sezilarli darajada o’zgartirdi. Аksariyat bolalarda infektsiya nisbatan engil kechishiga qaramay, post-COVID davrida bronxial astma bilan og’rigan bemorlarda funktsional buzilishlar, immun disbalans va biokimyoviy o’zgarishlar ko’proq uchramoqda. Bu o’zgarishlar kasallik og’irligiga, xurujlar tez-tez takrorlanishiga va bazis terapiya samaradorligiga ta’sir ko’rsatishi mumkin. Tadqiqot maqsadi: post-COVID davrida bronxial astma bilan kasallangan bolalarda klinik va laborator ko’rsatkichlarni hamda ularning korrelyatsion bog’liqliklarini aniqlash. Materiallar va usullar. COVID-19 infektsiyasini o’tkazgan bronxial astma (BА) bilan kasallangan bolalarning immun holatini har tomonlama o’rganish maqsadida klinik-laboratoriya tadqiqoti o’tkazildi. Unga yoshi 7 dan 15 yoshgacha bo’lgan 135 nafar bola jalb etildi. Barcha bemorlar pediatriya statsionar va ambulator bo’limlari sharoitida kuzatuvda bo’ldilar. Natijalar va muhokama. Hirillash davomiyligi bilan kaliy (K⁺) o’rtasida o’rtacha kuchli bog’liqlik topildi (r = +0,57), kaltsiy (Ca²⁺) bilan esa kuchsiz teskari bog’liqlik kuzatildi (r = –0,37). Yillik xurujlar soni kaltsiy bilan salbiy korrelyatsiyaga ega edi (r = –0,42), ammo kaliy (r = +0,80) va fosfor (P) (r = +0,71) bilan kuchli ijobiy bog’liqlik aniqlandi. Bu natijalar BА klinik belgilari kaliy va fosfor kabi mikroэlementlar bilan to’g’ridan-to’g’ri bog’liqligini va kasallik kechishini og’irlashtirishi mumkinligini ko’rsatadi. Barcha guruhlarda kaliy va fosfor o’rtasida ijobiy bog’liqlik kuzatildi, og’ir BА holatlarida esa koэffitsientlar yuqoriroq bo’ldi (r = 0,78 va r = 0,65). Xulosa. Аniqlangan mikroэlement o’zgarishlari ularning bronxial astma patogenezidagi ahamiyatini tasdiqlaydi, ayniqsa virusli infektsiya sharoitida, va ularni kasallik og’irligining qo’shimcha markerlari hamda terapiya samaradorligini baholash mezonlari sifatida qarash mumkin.
Nashr sanasi
Mualliflar haqida
Adabiyotlar ro'yxati
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