BOLALARDA BRONXIAL ASTMA VA OZIQLANISH TRAKTIDAGI BUZILISHLARNING O‘ZARO BOG‘LIQLIGI: KLINIK-FUNKTSIONAL JIHATLAR
Abstract
This article is devoted to the study of clinical and functional features in children with bronchial asthma combined with gastrointestinal tract disorders. The work reviews current data on the prevalence of comorbid conditions in pediatric patients, their pathogenetic mechanisms, and clinical significance. Particular attention is paid to the relationship between immunological disorders, the state of the intestinal microbiota, and functional indicators of the respiratory system. The study demonstrated that in children with bronchial asthma and concomitant gastrointestinal diseases, the course of the illness is characterized by a higher frequency of exacerbations, significant changes in pulmonary function, reduced levels of fecal elastase-1, and dysbiotic alterations of the intestine. These factors are associated with more severe clinical manifestations, decreased effectiveness of basic therapy, and impaired quality of life. A comprehensive diagnostic approach, including assessment of respiratory function, gastrointestinal examination, analysis of the microbiota, and evaluation of immunological parameters, makes it possible to identify comorbid conditions in a timely manner and to individualize therapy. The findings emphasize the necessity of a multidisciplinary approach in the management of children with bronchial asthma and concomitant gastrointestinal disorders.
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