MICROCIRCULATORY CHANGES AND THEIR PROGNOSTIC SIGNIFICANCE IN CHILDREN WITH ATYPICAL PNEUMONIA
Abstract
Relevance. In recent decades, there has been an increase in the proportion of atypical pneumonias caused by pathogens such as Mycoplasma pneumoniae, Chlamydophila pneumoniae, less frequently Legionella pneumophila, and viral-bacterial associations.Objective. To study the features of microcirculatory disorders in children with atypical pneumonia and to assess their role in the formation of clinical course and prognostic significance of the disease. Materials and Methods. The study included 82 children diagnosed with atypical pneumonia who were hospitalized in the pulmonology department of the Andijan State Medical Institute between 2022 and 2024. The age of patients ranged from 3 to 15 years, with a mean age of 9.2 ± 3.1 years. Among the examined children, there were 45 boys (54.9%) and 37 girls (45.1%). Results. Clinical data analysis revealed that in children with atypical pneumonia, the severity of symptoms and the duration of illness were directly dependent on the severity of the disease. The average duration of fever in patients with mild pneumonia was 4.2 ± 1.1 days, with moderate pneumonia — 7.3 ± 1.8 days, and with severe pneumonia — 11.6 ± 2.4 days (p < 0.01 compared to mild cases). The duration of hospitalization also varied, from 8.4 ± 1.7 days in children with mild pneumonia to 18.2 ± 3.5 days in severe cases. Conclusions. The degree of microcirculatory changes depends on the severity of the disease: in mild cases, moderate perfusion disorders are observed; in moderate cases, pronounced stasis and reduced perfusion indices are noted; and in severe cases, there is a significant suppression of microcirculation up to critical hypoperfusion.
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