INTERRELATIONSHIP BETWEEN BRONCHIAL ASTHMA AND GASTROINTESTINAL TRACT DISORDERS IN CHILDREN: CLINICAL AND FUNCTIONAL ASPECTS
Abstrakt
Ushbu maqola bronxial astma va oshqozon-ichak trakti buzilishlari birgalikda kuzatiladigan bolalarda kliniko-funktsional xususiyatlarni o‘rganishga bag’ishlangan. Ishda pediatriya bemorlarida komorbid holatlarning tarqalishi, ularning patogenetik mexanizmlari va klinik ahamiyatiga oid zamonaviy ma’lumotlar ko‘rib chiqilgan. Xususan, immunologik buzilishlar, ichak mikrobiotasi holati va nafas olish tizimining funktsional ko‘rsatkichlari o‘rtasidagi o‘zaro bog’liqlikka alohida e’tibor qaratilgan. Tadqiqot shuni ko‘rsatdiki, bronxial astma va hamroh MIT kasalliklari bo‘lgan bolalarda kasallikning kechishi ko‘proq retsidivlar, tashqi nafas olish funktsiyasining ifodali o‘zgarishlari, fekal elastaza-1 darajasining pasayishi va ichakdagi disbiotik o‘zgarishlar bilan tavsiflanadi. Bu omillar klinik manzaraning og’irligi, bazis terapiyaning samaradorligining pasayishi va bemorlar hayot sifatining yomonlashishi bilan bog’liq. Diagnostikaga kompleks yondashuv, ya’ni nafas olish funktsiyasini baholash, JKTni tekshirish, mikrobiota va immunologik ko‘rsatkichlarni tahlil qilish komorbid holatlarni o‘z vaqtida aniqlash va terapiyani individuallashtirish imkonini beradi. Olingan ma’lumotlar bronxial astma va hamroh oshqozon-ichak trakti buzilishlari bo‘lgan bolalarni davolashda multidistsiplinar yondashuv zarurligini tasdiqlaydi.
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Mualliflar haqida
Adabiyotlar ro'yxati
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