FEATURES OF SYMPTOM COMPLEXES IN PRESCHOOL CHILDREN WITH ANEMIA
Abstract
Relevance. Anemia in preschool children remains one of the major medical and social problems in pediatrics, affecting physical and cognitive development, resistance to infections, and the formation of chronic pathologies (Ibragimova et al., 2020; Rakhimova et al., 2021). Latent asymptomatic anemia associated with vitamin and trace element deficiency is most commonly observed in children aged 3 to 7 years. Objective. To study the characteristics of clinical symptom complexes in preschool children with anemia of varying severity. Materials and Methods. The study involved 50 children aged 3–7 years diagnosed with community-acquired pneumonia. All patients were observed and treated in the Pulmonology Department of Campus-2 Clinic, Tashkent State Medical University. Results. Clinical and laboratory data of 50 preschool children with varying degrees of anemia were analyzed. Among them, 28 (56%) were boys and 22 (44%) were girls. The mean age was 3.5 ± 1.3 years. In the 3–4 year group, boys accounted for 58.6%, girls — 41.4%; in the 5–7 year group, boys — 65.5%, girls — 34.5%. According to medical records and maternal history, 34.5% of children were born full-term with a birth weight of 3050 ± 53 g; 25.6% were preterm (≈2010 ± 25.6 g), and 25.3% were low birth weight (900 ± 180 g). Anemia in preschool children was most frequent at 3–4 years of age, associated with a high incidence of infectious diseases and adaptive stress related to attending preschool institutions. As anemia severity increased (from grade I to II), a statistically significant (p < 0.01) decrease in protein and vitamin D. The high prevalence of clinical symptoms (hair and nail growth disorders, skin manifestations, decreased appetite) confirms the systemic nature of the anemic syndrome. Conclusion. Anemia in preschool children occurs most frequently between 3 and 4 years of age, linked to increased infection rates and adaptive stress during preschool attendance. With increasing severity of anemia, there is a statistically significant (p < 0.01) decline protein and vitamin D. The widespread clinical symptoms underline the systemic nature of anemia and emphasize the importance of early screening and correction of deficiency states in preschool children to prevent chronic pathologies.
Keywords:
About the Authors
List of references
Атаджанова, Ш., Арзикулов, А., Мелиева, Д., Акбарова, Р., Ну-ритдинова, Г. (2022). Клинико-анамнестические особенности динамики и трансформации железодефицитной анемии у девочек подростков. Международный журнал научной педиатрии, (3), 05-22. https:// doi.org/10.56121/2181-2926-2022-3-05-22/
Агульник А., Киргизов К.И., Янгутова Я.А., Муфтахова Г.М., Коган С.А., Серик Г.И., Робинсон Л., Серик Т.Г., Варфоломеева С.Р., Родригез-Галиндо К., Румянцев А.Г. Ситуационный анализ проблем и перспектив в области детской гематологии-онкологии на территории стран СНГ: опыт совместной рабочей группы. Российский журнал детской гематологии и онкологии (РЖДГиО). 2018;5(3):36- https:// doi.org/10.17650/2311-1267-2018-5-3-36-42
Дворецкий, Л. Ключевые вопросы лечения железодефицитной анемии // Врач. - 2017. - № 2. - С. 68-73. [3. Dvoretsky, L. Key issues in the treatment of iron deficiency anemia // Vrach. - 2017. - No. 2. - S. 68-73.]
Жорова, В. Е. Частота и распространенность железодефицитной анемии // Мед. совет. - 2018. - № 13. - С. 78-81. [5. Zhorova, V. E. Frequency and prevalence of iron deficiency anemia. // Med. advice. -2018. - No. 13. - P. 78-81]
Жуковская Е.В., Павлова Г.П., Румянцев А.Г. Нейрокогнитивные нарушения при сидеропенических состояниях у детей и подростков// Микроэлементы в медицине. -2017, 17(3)-С.-8-13. DOI: 10.19112/2413-6174-2016-17-3-8-13.
Захарова И.Н., Тарасова И.С., Чернов В.М. и др. Факторы риска развития железодефицитных состояний у детей и подростков города Москвы. Педиатрическая фармакология. 2018;1(8):69-75.
Захарова И.Н., Тарасова И.С., Васильева Т.М. и др. Латентный дефицит железа у детей и подростков: диагностика и коррекция. Лечение и профилактика. 2018;12(5):609-613
Заплатников А.Л., Кузнецова О.А., Воробьева А.С. и др. Алгоритм верификации характера анемии на основе корректной трактовки показателей клинического анализа крови. РМЖ. 2017;12:908-912.
Самкина О.Н., Водовозова Э.В., Леденева Л.Н. Эпидемиология железодефицитных анемий у детей раннего возраста, проживающих в спальном районе города Ставрополя . Российский вестник пе-ринатологии и педиатрии, 2017; 62:(4) стр 155-156.
Стуклов, Н. И. Анемия и дефицит железа. Глобальные проблемы и алгоритмы решений // Терапия. - 2018. - № 6. - С. 147— 156.
Armitage AE, Moretti D. The importance of iron status for young children in low- and middle-income countries: a narrative review. Pharmaceuticals (Basel). 2019;12(2). pii: E59.https://doi.org/10.3390/ ph12020059
Aksu T., Ünal Ş. Iron Deficiency Anemia in Infancy, Childhood, and Adolescence. Turk Arch Pediatr. 2023 Jul; 58(4):358–362. (Free PMC article, DOI: 10.5152/TurkArchPediatr.2023.23049).
Gallagher P.G.Anemia in the pediatric patient. Blood. 2022 Aug 11; 140(6):571–593.
Leung A.K.C., Lam J.M., Wong A.H.C., Hon K.L., Li X.
Iron Deficiency Anemia: An Updated Review. Curr Pediatr Rev. 2024; 20(3):339–356.
Liu Y.etal. Global burden of anemia and cause among children under five years 1990–2019: findings from the GBD Study 2019. Frontiers in Nutrition. 2024; (онлайн-статья, DOI: 10.3389/fnut.2024.1474664)
How to Cite

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.