YUVENIL IDIOPАTIK АRTRIT BILAN KASALLANGAN NEFROPATIYASI BOR BEMORLARDA SITOKINLАR
Qabul qilingan: 2025-03-15 08:59:21
Nashr etilgan: 2025-04-16
Annotatsiya
Tadqiqot maqsadi: Yuvenil idiopatik artrit va buyrak shikastlanishining erta tashxisida proyallig`lanish sitokinlarning rolini aniqlash. Materiallar va metodlar: Tadqiqotga 2021-2023 yillarda TTА koʼp tarmoqli tibbiyot markazining kardio-revmatologiya boʼlimida davolangan bemorlar haqidagi maʼlumotlar kiritilgan. Ularning orasidan: 105 ta yuvenil idiopatik artrit bilan kasallangan bemorlar, ular asosiy guruhni tashkil etadi. Nazorat guruhi esa Chilonzor tumani №35 Oilaviy poliklinikasida dispanser kuzatuvi otayotgan 30 ta amaliy sogʼlom bolalardan tashkil topdi. Har bir tadqiqot qilinayotgan bemorga chuqur klinik-immunologik va laborator-instrumental tekshiruvlar oʼtkazilgan. Natijalar: Tadqiqotdan kelib chiqib, bizning o`rganishda yuvenil idiopatik artritning davom etishi 3 oydan 8 yilgacha va koʼproq katta va oʼrta bo'g'imlar zararlanishi (tizza, boldir-tovon, tirsak) ko`rsatdi. Kasallikning persistlovchi kechuvi 28,9% bemorlarda va progressiv kechuvi 71% kuzatildi. Dalillarga koʼra, bolalarda bo`gim zararlanishi jinsga koʼra, oʼgʼil bolalarda ekssudativ komponentning kamroq ekanligi (39%), pastki bo`gimlarda produktiv-distrofik oʼzgarishlarning koʼproq (61%) namoyishi boʼlgan. Qizlarda esa yuqori bo`gimlarda ekssudatsiya 85% boʼlgan. Bemorlarning oʼrtacha yoshi 7 yoshni tashkil qildi. Rentgenologik tekshiruv natijalari asosan Shteynbrokker boʼyicha II darajani koʼrsatgan. Yuvenil idiopatik artrit bilan kasallangan bemorlarda, proyallig'lanish sitokinlar darajasi 5-10 baravar, kasallikning variantlariga qarab ko'payadi. Xulosa: Yuvenil idiopatik artrit kasallikning zamonaviy davrda rivojlanishi, shuningdek ichki organlarning shikastlanishini aks ettiruvchi kasallikning tajovuzkorligi va progressiv tusidir. Ayniqsa, buyraklar zararlanishining va kasallikning o`gir kechishini oldini olishning samarali usullarini izlash zarurligini ta'kidlaydi. Ya'ni proyallig'lanish sitokinlar (TNF-α), qon zardobida 2 martadan ko'proq YUAning dastlabki tashxisini qo'yish uchun ishlatilishi mumkin.
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