STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS

Abstract

Relevance. At present, there is a growing interest in studying the role of the central and especially the autonomic nervous system in the development and pathogenetic course of hypertension. However, many aspects of this disease remain insufficiently explored. In particular, the available literature lacks comprehensive scientific studies that describe catecholamine metabolism, the activity of the main catecholamine deamination enzyme-monoamine oxidase, the levels of the final deamination product (VMA), and lipid peroxidation products such as MDA. In recent decades, a priority area of scientific research has been the identification of informative and easily accessible laboratory and instrumental markers that enable early detection of hypertension in young individuals. Aim of the study. To investigate the characteristics of sympathoadrenal system dysfunction and lipid peroxidation processes in young individuals engaged in the IT profession. Materials and methods. A total of 90 men aged 25-44 years were examined; the mean age was 33,2±0.93 years. Clinical, instrumental, and specific laboratory methods were used. Results and conclusions. It was found that young individuals actively engaged in the IT profession exhibit disorders in the functional activity of the sympathoadrenal system, manifested by increased excretion of catecholamines (particularly adrenaline and noradrenaline), disruption of the circadian rhythm of catecholamine excretion, reduced activity of monoamine oxidase (MAO) — the key enzyme responsible for catecholamine deamination — increased levels of vanillylmandelic acid, a secondary metabolite of catecholamines, as well as elevated malondialdehyde (MDA), a secondary product of lipid peroxidation.