IT SOHASI BILAN SHUG‘ULLANUVCHI YOSHLARDA KATEXOLAMINLAR ALMASHINUVI SIRKAD RITMINI VA LIPIDLARNING PEREKSID OKSIDLANISH JARAYONLARINING O‘RGANISH
Abstrakt
Dolzarbligi. Yurak-qon tomir kasalliklarini erta aniqlash, oldini olish va davolashga qaratilgan davlat dasturlari amalga oshirilayotganiga qaramay, muammo dolzarbligicha qolmoqda. So‘nggi yillarda gipertonik kasallik patogenezida simpatoadrenal tizim (SAT) ning o‘rniga katta e’tibor qaratilmoqda. Tashqi omillar ta’sirida katexolaminlarning keskin ajralishi stressning dastlabki ko‘rinishi hisoblanadi, simpatik asab tizimining yuqori tonusi esa yoshlar orasida arterial gipertenziya rivojlanishining asosiy mexanizmlaridan biri sifatida ko‘riladi. Tadqiqot maqsadi. IT sohasida faoliyat yurituvchi yoshlar orasida simpatoadrenal tizim buzilishlari va yog‘larning perekis oksidlanish jarayonlari xususiyatlarini o‘rganish. Material va metodlar. 25–44 yoshdagi 90 nafar erkak tekshirildi, o‘rtacha yosh -33,2±0,93 yosh. Klinik, instrumental va maxsus tadqiqot usullari qo‘llanildi. Natijalar va xulosa. IT sohasi bilan shug‘ullanuvchi yoshlar populyatsiyasida simpatoadrenal tizimning funksional faolligi buzilganligi aniqlandi. Bu holat katexolaminlar, xususan adrenalin va noradrenalinning sutkalik ekskresiyasining oshishi, katexolaminlar ekskresiyasining sirkad ritmi buzilishi, katexolaminlarni dezaminlashning asosiy fermenti bo‘lgan monoaminooksidaza (MAO) faolligining pasayishi, katexolaminlar metabolizmining ikkilamchi mahsuloti-vanillinmindal kislotasining ko‘payishi, shuningdek yog‘larning perekis oksidlanishining ikkilamchi mahsuloti-malon dialdegid (MDA) miqdorining ortishi bilan namoyon bo‘ladi.
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