INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN

Abstract

Relevance. Nephrotic syndrome (NS) in children is a common kidney disorder often associated with immune and endocrine imbalance. Thyroid hormone changes may affect NS pathogenesis, clinical manifestations, and treatment response.  Purpose of the study Evaluation of the effect of thyroid dysfunction on the clinical manifestations of NS in children. Materials and methods of the study. Eighty children (1–18 years) with NS and 30 healthy controls were studied. According to serum TSH, T3, and T4, patients were divided into groups with normal thyroid function, hypothyroidism, and hyperthyroidism. Clinical, biochemical, ultrasound, and immunological parameters were evaluated. Research results. Subclinical hypothyroidism was common in active NS. In hypothyroid patients, edema lasted longer, hypoproteinemia, hypercholesterolemia, and proteinuria were more severe (p<0,05), with frequent relapses and corticosteroid dependence. Conclusion. Thyroid dysfunction increases NS severity. Regular thyroid evaluation and endocrinologist involvement are crucial in pediatric management.