BOLАLАRDА NEFROTIK SINDROM OGʼIRLIGIGА TIREOID GORMONАL DISBАLАNSNING TА’SIRI
Abstrakt
Mavzuning dolzarbligi. Nefrotik sindrom (NS) bolalarda keng tarqalgan nefrologik kasallik boʼlib, klinik kechishi koʼp hollarda immunologik va endokrin disbalanslar bilan bogʼliq. Tireoid gormonlaridagi oʼzgarishlar NS patogenezi, klinik kechishi va davolash samaradorligiga taʼsir koʼrsatishi mumkin. Maqsad. Bolalarda NS klinik koʼrinishlariga tireoid disfunktsiyasining taʼsirini baholash. Tadqiqot materiallari va usullari. 1–18 yoshdagi 80 nafar NS tashxisli bemor va 30 nafar sogʼlom bolalar guruhi tekshirildi. Bemorlar tireoid gormonlari (TTG, T3, T4) darajalariga koʼra normofunktsiya, gipofunktsiya va giperfunktsiya guruhlariga ajratildi. Klinik, laborator va biokimyoviy koʼrsatkichlar, UZI va immunologik tahlillar baholandi. Tadqiqot natijalari. NS faol davrida aksariyat bemorlarda subklinik gipotireoz aniqlandi. Gipofunktsiya guruhida shish uzoq davom etdi, gipoproteinemiya va giperxolesterinemiya kuchli ifoda etildi, proteinuriya davomiyligi ortdi (p<0,05). Retsidivlar va kortikosteroidlarga tobelik koʼproq qayd etildi. Xulosa. Tireoid disfunktsiyasi NS klinik ogʼirligini belgilaydi. Shuning uchun bolalarda tireoid statusini muntazam baholash va endokrinolog ishtirokida davolash taktikasi belgilanishi zarur.
Nashr sanasi
Mualliflar haqida
Adabiyotlar ro'yxati
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