Jild 5 № 2 (2026): Mart-Aprel
74-82
2026-04-30
Ochiq kirish

Homiladorlikning jigar ichi xolestazida paritetga bog‘liq bo‘lgan oshqozon osti bezining morfologik va morfometrik o‘zgarishlari: autopsiya tadqiqoti

Bobur Hoshimov
Sherzod Kenjayev
https://doi.org/10.56121/MSU-2026-2-00012

Qabul qilingan: 2026-02-27

Nashr etilgan: 2026-04-30

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Annotatsiya

Maqsad. Homiladorlikning intrahepatik xolestazi (HIX) tufayli vafot etgan ayollarda oshqozon osti bezi morfologik va morfometrik o‘zgarishlarini, shuningdek, ularning jigar shikastlanishi va homiladorliklar soni bilan bog‘liqligini tavsiflash.
Materiallar va usullar. O‘tkir miokard infarktidan vafot etgan 12 nafar tug‘ruq yoshidagi nazorat guruhi ayollari bilan taqqoslaganda, og‘ir HIX tufayli vafot etgan 51 nafar ayolning jigar va oshqozon osti bezi to‘qimalarida autopsiyaga asoslangan morfologik va miqdoriy morfometrik tadqiqot o‘tkazildi (Respublika patologik anatomiya ilmiy-amaliy markazi, 2013–2023-yillar). 28 ta asosiy holat va nazorat guruhidan olingan kesmalar gematoksilin-eozin bilan bo‘yalib, morfometriya (12 ta parametr) uchun raqamlashtirildi; o‘rtacha qiymatlar Styudentning t-mezoni yordamida taqqoslandi.
Natijalar. HIX kuzatilgan jigarlarda sentrilobulyar va midzonal gepatotsellyulyar xolestaz, o‘t pigmentining to‘planishi, gidropik distrofiya va nekrobioz (54,2%), 75% holatda esa kanalikulyar o‘t dimlanishi aniqlandi. Oshqozon osti bezida o‘tning yirik va bo‘lakchali yo‘llarga reflyuksi, segmentar atsinar nekroz, vakuolyar distrofiya, interstitsial shish, periduktal infiltratsiya va avj oluvchi fibroz kuzatildi. Barcha 12 morfometrik ko‘rsatkich nazorat guruhidan sezilarli darajada farq qildi (P<0,01–P<0,001) va o‘zgarishlar jiddiyligi homiladorliklar soniga qarab ortib, ayniqsa uchinchi va to‘rtinchi homiladorlikda yaqqol namoyon bo‘ldi.
Xulosa. HIX – bu o‘t kislotalari ta’sirida yuzaga keladigan tizimli toksik holat bo‘lib, u jigar xolestazi bilan birga oshqozon osti bezining miqdoriy jihatdan baholanadigan va homiladorliklar soniga bog‘liq bo‘lgan shikastlanishini keltirib chiqaradi. Bu esa og‘ir yoki qaytalanuvchi HIX holatlarida oshqozon osti bezini sinchkovlik bilan kuzatib borish zarurligini tasdiqlaydi.

Kalit so‘zlar

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Mualliflar haqida

Bobur Hoshimov
talaba00719941995@gmail.com
Alfraganus universiteti
Sherzod Kenjayev
usmleu6@gmail.com
Farg'ona jamoat salomatligi tibbiyot instituti

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Homiladorlikning jigar ichi xolestazida paritetga bog‘liq bo‘lgan oshqozon osti bezining morfologik va morfometrik o‘zgarishlari: autopsiya tadqiqoti. MSU [Internet]. 2026 Apr. 30 [cited 2026 Aug. 23];5(2):74-82. Available from: https://fdoctors.uz/index.php/journal/article/view/280
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