Jild 5 Nomeri 1 (2026): Yanvar–Fevral
53-63
2026-02-27
Ochiq kirish

Kombinatsiyalashgan o‘tkir bosh miya jarohatlarida neyroendokrinologik ko‘rsatkichlarning kompleks diagnostikasi va prognostik jihatlari

Kahramonjon Kuldashev
Feruza xaydarova
Yayraxon Kuldasheva
Zilola Xakimova
Gulmira Inomova
DOI: https://doi.org/10.56121/MSU-2026-1-00006

Qabul qilingan: 2025-12-27 17:38:08

Nashr etilgan: 2026-02-27

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Annotatsiya

Kombinatsiyalashgan o‘tkir bosh miya jarohati travmatik omilning og‘irlik darajasiga qarab miya tuzilmalarining bevosita shikastlanishiga hamda uzoq joylashgan organlar faoliyatining buzilishiga olib keladi. Kombinatsiyalashgan o‘tkir bosh miya jarohatlarida neyroendokrin buzilishlar ko‘pincha yetarlicha aniqlanmaydi, bu esa kasallikning ham o‘tkir, ham surunkali bosqichlarida turli asoratlarning rivojlanishiga sabab bo‘ladi. Ushbu tadqiqotning maqsadi bemorlarni boshqarish protokollarini va umumiy yashab qolish ko‘rsatkichlarini yaxshilash uchun kombinatsiyalashgan o‘tkir bosh miya jarohatlaridagi neyroendokrinologik ko‘rsatkichlar bo‘yicha so‘nggi ilmiy dalillarni tahlil qilishdan iborat bo‘ldi. So‘nggi besh yil davomida ochiq ma’lumotlar bazalarida chop etilgan ilmiy maqolalar tahlil qilindi. Tadqiqot natijalariga ko‘ra, bosh miya jarohatlaridan keyin eng ko‘p uchraydigan neyroendokrin holatlar gipofizar yetishmovchilik, qandsiz diabet, gipotalamus disfunksiyasi va kognitiv buzilishlar ekanligi aniqlandi. Past arterial bosim (ham tizimli, ham intrakranial), anemiya va gipoksiya markaziy endokrin bezlarda ishemik o‘zgarishlarni yuzaga keltirishi mumkin. Kombinatsiyalashgan travmatik bosh miya jarohatlarining o‘tkir bosqichida somatotrop, gonadotrop va adrenokortikotrop gormonlar yetishmovchiligi belgilari ustunlik qiladi. O‘tkir bosqichdagi vazopressin yetishmovchiligi miya shishi rivojlanish xavfining ortishi bilan, oksitotsin yetishmovchiligi esa neyrodegenerativ patologiyalar rivojlanishi bilan bog‘liq. Neyroendokrin buzilishlarning differensial diagnostikasi anamnestik ma’lumotlar hamda bemorning biokimyoviy va gormonal ko‘rsatkichlari asosida amalga oshirilishi kerak. Olingan ma’lumotlar travmatik bosh miya jarohati bilan og‘rigan bemorlarni boshqarishda nevrologik buzilishlar bilan bir qatorda neyroendokrin buzilishlarni o‘z vaqtida aniqlash muhimligini ta’kidlaydi va ular birlamchi diagnostika hamda reabilitatsiya bosqichlarida qo‘llanishi mumkin.

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Mualliflar haqida

Kahramonjon Kuldashev
kulshev-23@mail.ru
Andijan State Medical Institute
Feruza xaydarova
alimovna@mail.ru
Respublika ixtisoslashtirilgan endokrinologiya ilmiy-amaliy tibbiyot markazi
Yayraxon Kuldasheva
faolguli@gmail.com
Andijan State Medical Institute
Zilola Xakimova
lola-zilola@mail.ru
Andijan State Medical Institute
Gulmira Inomova
gulmira.inomova94@gmail.com
Andijan State Medical Institute

Litsenziya

Mualliflik huquqi (c) 2026 O`zbekiston tibbiyot ilmi

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Kombinatsiyalashgan o‘tkir bosh miya jarohatlarida neyroendokrinologik ko‘rsatkichlarning kompleks diagnostikasi va prognostik jihatlari. MSU [Internet]. 2026 Feb. 27 [cited 2026 May 14];5(1):53-6. Available from: https://fdoctors.uz/index.php/journal/article/view/260
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