BRONXIAL ASTMA VA SURUNKALI OBSTRUKTIV O'PKA KASALLIGINING KOMBINATSIYALANGAN PATOLOGIYASI BO'LGAN BEMORLARDA ENDOTELIAL DISFUNKTSIYANING XUSUSIYATLARI
Qabul qilingan: 2025-03-22 17:55:03
Nashr etilgan: 2025-04-16
Annotatsiya
Kirish. Jahon sog'liqni saqlash tashkilotima'lumotlariga ko'ra, nafas olish yo'llari infektsiyasidan (ori) o'lim darajasi har doim yuqori bo'lgan, dunyo aholisining o'limining 10 ta asosiy sabablari ro'yxatiga kiritilgan. [1,9,10] Bronxial astma (BA) va surunkali obstruktiv o'pka kasalligi (O’SOK) – surunkali bronxial obstruktsiya bilan tavsiflangan nafas yo'llarining patologiyalari. Ikkala kasallik ham atrof-muhit omillari va inson tanasining o'zaro ta'siri natijasida yuzaga keladi, bu esa turli xil klinik ko'rinishlarga olib keladi. Tadqiqot maqsadi: bronxial astma, surunkali obstruktiv o'pka kasalligi va ikkalasining kombinatsiyasi bo'lgan bemorlarda endotelial disfunktsiyani shakllantirishda azot oksidi metabolitlarining rolini baholash. Tadqiqot materiallari va usullari: Samarqand shahar tibbiyot birlashmasining pulmonologiya va allergologiya bo'limida 115 nafar bemor, shuningdek, 20 nafar sog'lom insonlar tekshirildi. Natijalar va xulosalar: Endotelial disfunktsiyani aniqlash uchun biz NCHK tarkibida ham, qonda ham NO2 va NO3 ko'rsatkichlarining nisbatlarini o'rganib chiqdik. Natijalar shuni ko'rsatdiki, O’SOK +BA bilan og'rigan bemorlarda kasallikning izolyatsiya qilingan turi (P<0,05; p<0,001) bilan solishtirganda NO2 va NO3 kontsentratsiyasi kuchaygan, bu kasallikning kombinatsiyalangan bosqichida endotelial tizim disfunktsiyasining yuqori darajasini tasdiqlaydi.
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