STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA
Abstract
Objective: To study morphometric changes in the structure of the liver of white rats with polypharmacy with anti-inflammatory drugs.
Methods: The study was carried out on 50 male white rats, weighing from 210 to 320 g, kept in a vivarium with a standard diet, free access to water, and a normal lighting regime. The animals were divided into 3 groups.
Results: When comparing the morphometric parameters of the rats of the 3rd group with those of the 2nd group, a significant decrease was found. The area of the hepatic cell decreased 5.14%, 5.05%, 3.19% and 3.02%, the outer diameter of the central vena decreased 8.13%, 6.11%, 4.08% and 3.42%, the diameter of the biliary duct decreased by 6.33%, 5.09%, 3.12% and 3.08%, the outer diameter of the arterial decreased by 7.12%, 5.07%, 5.03% and 4.48%, the diameter of the hepatic biliary duct decreased by 4.47%, 4.04%, 3.07% and 2.31%.
Conclusions. The presence of the effect of polypharmacy by anti-inflammatory drugs on the liver indicates that polypharmacy has a detrimental effect on urinary excretion, reduces biliary excretion and has a sufficient level of risk for the body.
Keywords:
About the Authors
List of references
Norbekovich, T. B., Oblakulovich, K. S. O. S., Sadinovich, U. S., Mustafoevich, M. Z., & Akhmadjonovich, S. S. (2021). Polypragmasia as a risk factor causing complications in viral infection. Central Asian Journal of Medical and Natural Science, 2(2), 79-82.
Sadinovich, U. S., Oblakulovich, K. S., & Murodullaevna, K. L. (2023). Morphology and morphometric characteristics of liver tissue of group four white rats. Journal of biomedicine and practice, 8(3).
Usanov, S. S., & Teshaev, S. J. (2022). COMPARATIVE CHARACTERISTICS OF THE LIVER MORPHOMETRIC PARAMETERS OF WHITE UNBORED RATS IN NORMALITY AND WITH THE ACTION OF 2 DIFFERENT ANTI-INFLAMMATORY PREPARATIONS IN POLYPRAGMASIA. Oriental renaissance: Innovative, educational, natural and social sciences, 2(1), 68-74.
Усанов, С. С. (2021). ХАРАКТЕРИСТИКА МОРФОМЕТРИЧЕСКИХ ПАРАМЕТРОВ ПЕЧЕНИ ПРИ ПОЛИПРАГМАЗИИ. Oriental renaissance: Innovative, educational, natural and social sciences, 1(8), 613-621.
Sadinovich, U. S., & Ismoilovich, I. O. (2022). ОQ ZOTSIZ KALAMUSHLAR JIGARINING MORFOMETRIK KO‘RSATGICHLARINI POLIPROGMAZIYADA YALLIG‘LANISHGA QARSHI 4 HIL VOSITALAR TA’SIRI HOLATIDA O‘RGANISH. JOURNAL OF BIOMEDICINE AND PRACTICE, 7(5).
Usanov, S. S. (2022). Anatomical and Histological Parameters of the Liver of White Nonbored Rats in Normal. BARQARORLIK VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY JURNALI, 2(1), 123-128.
Usanov, S. S., & Zh, T. S. (2022). Study of Morphological Changes in the Liver of White Unbored Rats under the Influence of 3 Different Anti-Inflammatory Preparations. BARQARORLIK VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY JURNALI, 2(1), 129-132.
Usanov, S. S., Teshaev, S. J., & Sanoev, B. A. (2022). MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE LIVER OF WHITE NONBORED RATS IN NORMAL. Oriental renaissance: Innovative, educational, natural and social sciences, 2(1), 75-81.
Sadinovich, U. S. (2021). Characteristic Of The Morphometric Parameters Of The Liver In Polypragmasia. The American Journal of Medical Sciences and Pharmaceutical Research, 3(10), 28-32.
Усанов, С., Хидиров, З., & Олимова, Ж. (2023). ОҚ ЗОТСИЗ КАЛАМУШЛАР ЖИГАРИНИНГ МЕЪЁРДАГИ МОРФОЛОГИК ВА МОРФОМЕТРИК ПАРАМЕТРЛАРИ. Евразийский журнал академических исследований, 3(11), 101-107.
Sadinovich, U. S., Erkinovich, K. Z., & Abdurafikovich, D. H. (2023). Study Of The Morphometric Indicators Of The Liver Of Album Rats Under The Effect Of 3 Different Anti-Inflammatory Medicines In Polyprogramsis. Central Asian Journal of Medical and Natural Science, 4(6), 450-455.
Sanjar, U. (2022). MORPHOLOGICAL FEATURES OF THE LIVER IN POLYPRAGMASIA. YANGI O‘ZBEKISTONDA MILLIY TARAQQIYOT VA INNOVASIYALAR, 127-129.
Мустафоев, З. М., Абдураимов, З. А., & Мавлонкулова, Д. М. (2023). МОРФОМЕТРИЧЕСКАЯ КЛАССИФИКАЦИЯ ОТДЕЛОВ НЕФРОНА КРЫС И ОПРЕДЕЛЕНИЕ ИЗМЕНЕНИЙ ЭФФЕКТА ПОЛИПРАГМАЗИИ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ. Research Focus, 2(11), 119-123.
Khidirov, Z. E., & Zafarjon, A. (2023). Views on" Postcholecystectomy Syndrome". Central Asian Journal of Medical and Natural Science, 4(3), 200-206.
Zafarjon, A., & Khidirov, Z. E. (2023). MAIN CAUSES, DIAGNOSIS, AND EFFECTIVE TREATMENT OF POSTCHOLECYSTECTOMY SYNDROME. World Bulletin of Public Health, 21, 223-228.
Abduraimov, Z., & Khidirov, Z. (2023). RESTORATION OF MORPHOLOGICAL STRUCTURES IN THE WALL OF THE SMALL INTESTINE. Евразийский журнал медицинских и естественных наук, 3(10), 103-107.
Abduraimovich, A. Z., & Erkinovich, Н. Z. (2023). MORPHOFUNCTIONAL CHARACTERISTICS OF THE SMALL INTESTINE DURING EXPERIMENTAL CHOLECYSTECTOMY AND ANTIHYPOXANT THERAPY IN ACUTE SMALL INTESTINAL OBSTRUCTION. Journal of Universal Science Research, 1(10), 222-229.
Мустафоев, З. М., Абдураимов, З. А., & Мавлонкулова, Д. М. (2023). МОРФОМЕТРИЧЕСКАЯ КЛАССИФИКАЦИЯ ОТДЕЛОВ НЕФРОНА КРЫС И ОПРЕДЕЛЕНИЕ ИЗМЕНЕНИЙ ЭФФЕКТА ПОЛИПРАГМАЗИИ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ. Research Focus, 2(11), 119-123.
Абдураимов, З. А., Коржавов, Ш. О., Шамсиева, Р. А., Шавкатуллаева, Д. Г., Хасанова, М. Б., & Негматов, Х. И. (2013). ПУТИ УСТРАНЕНИЯ ПОСЛЕОПЕРАЦИОННЫХ ОСЛОЖНЕНИЙ ПРИ ПЛАСТИКЕ ВЕНТРАЛЬНЫХ ГРЫЖ У БОЛЬНЫХ С СОПУТСТВУЮЩИМ ОЖИРЕНИЕМ. SCIENCE AND WORLD, 50.
Erdanovich, R. K., Sulaimanovich, D. S., Shukurillaevich, A. D., & Abduraimovich, A. Z. (2022). Criteria For Selecting Surgical Treatment Of Patients With Vental Hernias And Obesity. Periodica Journal of Modern Philosophy, Social Sciences and Humanities, 3, 40-46.