Jild 5 № 2 (2026): Mart-Aprel
61-73
2026-04-30
Ochiq kirish

Oʻtkir va surunkali alkogolli pankreatitda regionar va mezenterial limfa tugunlarining patomorfologiyasi: qiyosiy autopsiya tadqiqoti

Azizbek E.Latibjonov
Yulduz A.Musaeva
https://doi.org/10.56121/MSU-2026-2-00011

Qabul qilingan: 2026-02-27

Nashr etilgan: 2026-04-30

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Annotatsiya

Maqsad. Oʻtkir va surunkali alkogolli pankreatitda peripankreatik (regionar) va mezenterial limfa tugunlarining patomorfologik oʻzgarishlarini tavsiflash va qiyoslash, ularning immunopoetik hamda toʻsiq-filtratsiya vazifalari buzilishining tuzilmaviy asoslarini aniqlash.


Materiallar va usullar. Surunkali alkogol isteʼmoli klinik-anamnestik jihatdan tasdiqlangan shaxslar autopsiyasida olingan peripankreatik va mezenterial limfa tugunlari oʻrganildi. Kesmalar gematoksilin-eozin, van Gizon va alsian koʻki bilan boʻyalib, toʻrtta morfofunksional maydon (kapsula va sinuslar, poʻstloq, parakorteks, magʻiz qavat) boʻyicha yarim miqdoriy baholandi.


Natijalar. Oʻtkir shakllarda barcha maydonlarni qamrab olgan kuchli interstitsial shish, subkapsulyar va oraliq sinuslarning kengayishi, kapsulaning dezorganizatsiyasi va poʻstloq limfoid follikulalarining sekvestratsiyasi ustunlik qildi. Surunkali shakllarda parenximaning atrofiyasi, stroma-tomir tuzilmalarining proliferatsiyasi va sklerozi, kapsulaning qalinlashuvi, magʻiz qavatda neoangiogenez, sinus gistiotsitozi va retikuloskleroz aniqlandi. Har ikki guruhda parakortikal postkapillyar venulalar yuqori endoteliyli fenotipini yoʻqotib, limfotsitlar migratsiyasisiz yupqa devorli toʻlaqonli venalarga aylandi.


Xulosa. Alkogolli pankreatit bosqichga bogʻliq, noinfeksion limfadenopatiya chaqiradi va u shishli-destruktiv shakldan atrofik-sklerotik qayta qurilishga oʻtadi.

Kalit so‘zlar

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Mualliflar haqida

Azizbek E.Latibjonov
talaba00719941995@gmail.com
Farg'ona jamoat salomatligi tibbiyot instituti
Yulduz A.Musaeva
yulduz76m@gmail.com
Toshkent davlat tibbiyot universiteti

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Oʻtkir va surunkali alkogolli pankreatitda regionar va mezenterial limfa tugunlarining patomorfologiyasi: qiyosiy autopsiya tadqiqoti. MSU [Internet]. 2026 Apr. 30 [cited 2026 Aug. 13];5(2):61-73. Available from: https://fdoctors.uz/index.php/journal/article/view/279
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