Medical science of Uzbekistan

EMOTIONAL INSTABILITY AND NEUROTICISM AS RISK FACTORS FOR PSYCHOSOCIAL BRUXISM (Brief overview)

Abdukadirova Amaliya Mamatraimovna, Lorenz Daniel Detlef — Sat, 30 Aug 2025 00:00:00 +0500

This overview study aims to determine the connection between neuroticism as a personality factor and bruxism symptoms in adults. The research includes a review of current data and exploration of clinical and psychological relationships. The results suggest that neuroticism relates to a higher chance of both daytime and nighttime bruxism, mainly through anxiety, somatization, and reduced emotional control.

IMPROVING THE EFFECTIVENESS OF PREVENTION AND TREATMENT METHODS FOR INFLAMMATORY COMPLICATIONS AFTER COMPLEX TOOTH EXTRACTION

Bekmuratov Lukmon Rustamovich, Ashrapov Yosinkhon Akhmat ugli — Sat, 30 Aug 2025 00:00:00 +0500

Inflammatory complications following complex tooth extraction remain among the most common and clinically significant issues in outpatient oral and maxillofacial surgery. This review explores the etiology and pathogenesis of postoperative inflammation, the classification and clinical forms of complications, and current strategies for their prevention and treatment. Special attention is given to the analysis of the effectiveness of various therapeutic approaches, including both traditional methods and innovative technologies such as photodynamic therapy, PRF/PRP, and laser applications. The article also provides recommendations on the standardization of clinical protocols, professional training, and promising directions for future research. The importance of a comprehensive, integrative approach is emphasized as the most effective strategy for reducing the incidence of postoperative inflammatory complications.

THE ROLE OF SOD2 GENE ALA16VAL POLYMORPHISM IN THE DEVELOPMENT OF MYELOPROLIFERATIVE NEOPLASIA IN KHOREZM REGION

Sat, 30 Aug 2025 00:00:00 +0500

Objective: To assess the influence of allelic and genotypic variants of the Ala16Val polymorphism in the SOD2 gene on the development of myeloproliferative neoplasms (MPNs).

Materials and methods: A study was conducted on 110 patients with clinically and genetically confirmed Ph-positive and Ph-negative MPNs to investigate the role of the SOD2 gene Ala16Val polymorphism in the development and prognosis of MPN clinical course. Of these, 34 patients (CML – 26, ET – 7, PMF – 1) resided in unfavorable regions of the Khorezm region (Group I) and 76 patients (CML – 40, ET – 24, PMF – 10, PV – 2) resided in relatively favorable regions of the republic, including the Khorezm region (Group II). DNA samples from 105 unrelated ethnically Uzbek healthy controls were used. (Note: Abbreviations like CML, ET, PMF, PV need to be defined in the methods section or in a table).

Results: Statistical data suggest a potential association between the alleles (χ²=3.9; p=0.05) of the Ala16Val polymorphism in the SOD2 gene and the development of myeloproliferative neoplasms. The Ala allele plays a protective role in the development of MPNs, while the Val allele plays a pathogenic role; the presence of the Val allele indicates an increased risk of the disease. The mutant homozygous Val/Val genotype increases the risk of developing MPNs in patients from unfavorable regions more than twofold (χ²=4.0; p=0.05; =2.4; 95% CI: 1.02-5.57).

The p-values are borderline significant. The confidence intervals for the relative risk and odds ratio are quite wide, suggesting a need for larger sample sizes to confirm these findings. The abbreviations for the MPN subtypes should be clearly defined (e.g., CML = Chronic Myelogenous Leukemia, ET = Essential Thrombocythemia, PMF = Primary Myelofibrosis, PV = Polycythemia Vera).

IMPROVING THE EFFECTIVENESS OF TREATMENT FOR ODONTOGENIC PERIOSTITIS IN ELDERLY PATIENTS

Bekmuratov Lukmon Rustamovich, Xursanova Saodat Abdurashit qizi — Sat, 30 Aug 2025 00:00:00 +0500

Odontogenic periostitis is one of the most common inflammatory diseases of the maxillofacial region and is particularly relevant in elderly patients. Age-related changes in the immune system, the presence of comorbid conditions, and a high degree of polymorbidity significantly complicate the clinical course and require a revision of standard treatment approaches. This review article analyzes current therapeutic strategies for odontogenic periostitis with regard to geriatric-specific features, highlights the principles of personalized care, emphasizes the importance of interdisciplinary collaboration, and discusses promising research directions, including the development of adapted clinical protocols, and the use of innovative technologies.

RECURRENT PREECLAMPSIA

Sat, 30 Aug 2025 00:00:00 +0500

Recurrent preeclampsia is one of the most clinically significant forms of hypertensive disorders of pregnancy, associated with increased risks for both the mother and the fetus. The recurrence of preeclampsia warrants particular attention in terms of pathophysiological understanding, early identification of risk factors, and the development of preventive strategies. Materials and methods of the study.This review synthesizes current literature retrieved from PubMed, Scopus, Web of Science, ScienceDirect, and the Cochrane Library. The selection included original studies, systematic reviews, meta-analyses, and clinical guidelines published primarily over the past ten years. Special emphasis was placed on studies addressing recurrent preeclampsia, its long-term consequences, and individualized management approaches.

THE IMPORTANCE OF FEEDING TYPE IN NEONATAL PHYSIOLOGICAL JAUNDICE

Ochilova Shakhnoza Muzaffarovna — Sat, 30 Aug 2025 00:00:00 +0500

Physiological jaundice in newborns is a widespread condition, often resulting from the accumulation of bilirubin in the blood. This research article aims to analyze the impact of feeding methods (breastfeeding versus formula feeding) on the development and duration of physiological jaundice. Systematic literature review revealed that jaundice occurs more frequently and lasts longer in breastfed infants. However, this condition is primarily associated with inadequate milk intake or improper breastfeeding techniques. Research findings indicate that properly organized breastfeeding plays a crucial role in preventing jaundice. In conclusion, while breastfeeding remains preferable, medical supervision and proper breastfeeding techniques are essential.